We see many patients following an ACL reconstruction surgery who continue to feel a “certain weakness” or a “looseness” in their knee they were not expecting following the surgery and the extensive sports medicine rehab program they had gone through. Prior to the ACL surgery, most were made aware that there was a chance the graft would fail or that they would not be able to resume activities at the level that they wanted to. For most they had hoped that this would not be the case for them.
We will also be contacted by the parents of a high school age athlete who has already had the ACL reconstruction surgery, some with leading sports medicine specialists with the hopes that the surgery will allow them to continue their high school and college sports career. These parents are now concerned that their son or daughter has complained about their knee giving way and a follow up MRI revealed “a high signal” or an image of some type of deficient in the ACL graft. Now they are back at the sports medicine specialists look for revision surgery.
The problem of a “slightly loose” bone-patellar tendon-bone graft
People do have loose knees after ACL reconstruction. This is pointed out by a sports medicine study from March 2021. (1)
“In spite of supposedly successful surgery, slight residual knee laxity may be found at follow-up evaluations after anterior cruciate ligament reconstruction (ACLR), and its clinical effect is undetermined.”
In this sports medicine study, 234 soccer, team handball, and basketball players undergoing ACLR using bone-patellar tendon-bone graft. Using various tests, players were divided into post-surgical groups of “tight” ACL and “slightly loose” ACL. What these researchers identified was that the tight graft people and the loose graft people, functioned about the same sports level. At least for a little while. What happened?
“The rate of return to pivoting sports was 74% among athletes with tight grafts and 70% among those with slightly loose grafts. Also, return to preinjury level of sports was similar between those with slightly loose and tight grafts (40% vs 48%, respectively), but median duration of the sports career was longer among patients with tight grafts: 6 years vs 2 years.
Five slightly loose grafts (28%) and 6 tight grafts (5%) were classified as failures after 2 years.
A slightly loose graft at 6 months after ACLR increased the risk of later ACL revision surgery and/or graft failure, reduced the length of the athlete’s sports career, caused permanent increased anterior laxity, and led to an inferior Lysholm score (a test measuring knee function and pain symptoms).”
The researchers of this study pointed out the there was not much difference between what they considered a “slight loose” graft compared to a tight graft. To patients needing a second ACL reconstruction it made all the difference.
Sports medicine dilemma: The graft did not take.
A May 2021 paper (2) suggested that after everything else is reviewed, from surgical technique and rehabilitation techniques, graft failure maybe simply a case that the graft did not take. These are some of the points the researchers stressed:
- The graft failure rate after ACLR is still relatively high despite advances in surgical techniques and optimizing rehabilitation protocols, and the reason may be because of unfavorable healing process.
- The true incidence of ACL graft failure after implantation is unknown at present although as high as 24.4% has been reported.
- A study by the University of Pittsburgh showed that after single-bundle ACL reconstruction, the most common rupture pattern seen at the time of revision surgery is proximal (mainly at the attachments) rupture, followed by mid-substance rupture. (The graft is gradually or acutely cut in half by the lateral femoral condyle or bottom of the thigh bone).
- They also classified the mechanisms of ACL graft failure as related to
- (a) surgical technique;
- (b) graft incorporation; and
- (c) trauma.
- Since sports medicine advances have been made in surgical techniques and rehabilitation methods, when graft failure happens following ACL reconstruction without traumatic events, problematic graft healing should be considered. (The graft did not “take”)
The problem of a loose anterior cruciate ligament graft causing the need for a revision ACL surgery reconstruction
A 2019 sports medicine study (3) then examined a second or revision ACL surgery’s ability to fix this looseness.
The study authors examined:
- Patients who underwent primary and revision ACL reconstruction.
- Inclusion criteria were: same patients who underwent primary hamstring tendons and revision bone-patellar tendon-bone autograft ACLR, no associated ligament injuries and no contralateral ACL injuries/reconstructions.
- The cause of revision ACLR was graft rupture for all patients.
- A total of 118 patients with primary and revision ACLR arthrometric laxity measurements were available.
The mean preoperative and postoperative anterior side-to-side difference values were not significantly different between primary and revision ACLR. However, primary ACLR showed a significantly higher frequency of postoperative anterior side-to-side difference difference compared with revision ACLR.
Conclusions: “The findings of this study showed that anterior knee laxity is restored with revision bone-patellar tendon-bone autograft ACLR after failed primary hamstring tendons autograft ACLR, in the same cohort of patients. However, revision ACLR showed a significantly inferior functional knee outcome compared with primary ACLR. It is important for clinicians to inform and set realistic expectations for patients undergoing revision ACLR. Patients must be aware of the fact that having revision ACLR their knee function will not improve as much as with primary ACLR and the final postoperative functional outcome is inferior.”
Does it matter which graft you use?
A study in The American journal of sports medicine (4) wrote that: “Physicians’ and patients’ decision-making process between bone-patellar tendon-bone and hamstring tendon autografts for anterior cruciate ligament (ACL) reconstruction (ACLR) may be influenced by a variety of factors in the young, active athlete.” The researchers then set out to determine the incidence of both ACL graft revisions and contralateral ACL tears resulting in subsequent ACLR in a group of high school- and college-aged athletes who initially underwent primary ACLR with either a bone-patellar tendon-bone or a hamstring autograft. What did they discover? The odds of ACL graft revision were 2.1 times higher for patients receiving a hamstring autograft than patients receiving a BTB autograft. No significant differences were found between autograft choices when looking at the incidence of subsequent ACLR in the contralateral (the other knee) knee. However they concluded that “there was a high incidence of both ACL graft revisions and contralateral normal ACL tears resulting in subsequent ACLR in this young athletic cohort.”
Revision ACL Reconstruction can fail because of a loose knee after ACL Reconstruction
A 2020 sports medicines study (5) takes us all the way through the three stages, loose knee after ACL Reconstruction, ACL Reconstruction Revision, and ACL Reconstruction Revision Failure. The summary of this study states: “The most important finding of this study was that preoperative medial knee instability is a risk factor for revision ACL Reconstruction and should be adequately addressed at the time of revision ACL Reconstruction. This study demonstrates the largest revision ACL Reconstruction patient group with pre- and postoperative clinical examination data and a follow-up of 2 years published to date and it indicates that preoperative knee instability is an important factor for the treatment strategy of revision ACLR. Medial knee instability, high-grade anterior knee instability and increased posterior tibial slope are risk factors for failure of revision ACLR and should be addressed at the time of revision surgery.
So what are your options? Regenerative treatment? Regenerative treatment?
The ACL’s main function is to keep the thigh and shin bones aligned within the knee. When the ACL graft is loose or the knee unstable, the reconstruction can fail. It may be possible however to strengthen the graft with regenerative injection therapies.
Many orthopedists and sports medicine specialists may not recommend ACL reconstruction because it is not realistic for the patient. These recommendations may be made to patients who have an isolated ACL tear and did not include meniscus damage, other ligament tearing, or cartilage tear.
Our ACL treatment options can be found here in my article on ACL treatment options. Here I discuss the stem cell injection and the stem cell treatment.
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1 Lindanger L, Strand T, Mølster AO, Solheim E, Inderhaug E. Effect of Early Residual Laxity After Anterior Cruciate Ligament Reconstruction on Long-term Laxity, Graft Failure, Return to Sports, and Subjective Outcome at 25 Years. The American Journal of Sports Medicine. 2021 Mar 3:0363546521990801.
2 Yao S, Fu BS, Yung PS. Graft healing after anterior cruciate ligament reconstruction (ACLR). Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology. 2021 Jul 1;25:8-15.
3 Cristiani R, Engström B, Edman G, Forssblad M, Stålman A. Revision anterior cruciate ligament reconstruction restores knee laxity but shows inferior functional knee outcome compared with primary reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy. 2019 Jan;27(1):137-45.
4 MOON Knee Group, Spindler KP, Huston LJ, Zajichek A, Reinke EK, Amendola A, Andrish JT, Brophy RH, Dunn WR, Flanigan DC, Jones MH. Anterior cruciate ligament reconstruction in high school and college-aged athletes: Does autograft choice influence anterior cruciate ligament revision rates?. The American journal of sports medicine. 2020 Feb;48(2):298-309.
5 Alm L, Krause M, Frosch KH, Akoto R. Preoperative medial knee instability is an underestimated risk factor for failure of revision ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2020;10.1007/s00167-020-06133-y. doi:10.1007/s00167-020-06133-y