Marc Darrow MD,JD

The hip joint, the shoulder joint, the knee joint, the big toe joints, they all have one thing in common. When they are in the process of wear and tear degenerative joint disease, they become unstable, painful, and they start forming bone spurs and bony overgrowths. Sometimes the person suffering from degenerative joint disease will let this condition of joint instability go on for too long. This will cause the bone spurs to become too large and they will freeze up the joint, making it stiff and unmoveable, and, necessitating a need for surgery to shave down the bones. In the big toe, this bone spur or overgrowth is commonly referred to as a bunion.

In this article I will discuss with you the two main type of patients we see with big toe pain. The patient who has big toe joint instability that can be helped with PRP and stem cell therapy injections and the patient with a large bunion and what we may be able to do for them.

The big toe has two joints

  • metatarsophalangeal joint (the bunion joint)
  • interphalangeal joint (the joint under the toenail)

The metatarsophalangeal joint is where we will concentrate this article.

Before the bunion – “Turf toe.”

A 2020 study in the journal Foot and ankle surgery (1) sought to expand the understanding of big toe instability or “turf toe,” as “a wide variety of traumatic lesions of the first metatarsophalangeal joint).” “Turf toe,” refers to injuries typically sustained by athletes who play on turf. These are lesions (tears and damage) are typically difficult to diagnose, with a large variation of outcomes and a potential to impair patients’ functional performance on a definitive and perennial basis.” In other words, big toe pain can be caused by many things and cause a lot of problems. Treatment has been challenging because doctors have focused on a limited aspect of the big toe pain – the metatarsophalangeal joint and not the understanding of the whole foot dynamic.

The researchers of this study used their “Expanded Turf-toe” diagnosis, incorporating various injuries originally thought to be outside the traditional diagnosis of “Turf toe.” This would include injuries to someone, maybe like yourself, who is not athletic but suffers from the same type of toe pain and instability.

  • The most frequent cause of injury was axial load with various direction of stress at the first MTP. (This would be a position where your toes would be flat on the ground and your heel would be several inches off the ground. A position achieved by the wearing of high heeled shoes or toe raising exercise.)

This injury caused these problems typical of whole joint instability:

  • hallux varism (the anatomical distorting of the big toe) in 42% of the study subjects
  • pure hyperextension (the toe is exceeding is normal range of motion) in 42% of the study subjects,
  • extension with hallux valgism (The beginnings of the formation of a bunion to stop the abnormal range of motion from causing more damage in 21% of the study subjects),
  • pure hyperflexion (the muscles of the toe are now extending beyond their normal range of motion) in 8% of the study subjects,
  • and hyperflexion with hallux valgism (the muscles of the toe are now extending beyond their normal range of motion with bunion formation starting) in 4% of the study subjects,

With all this instability and hypermobility it is easy to understand your toes’ desire to start forming bone spurs to keep itself together.

In this video you see how Dr. Darrow performs treatment. One treatment is not one injection.

PRP and stem cell therapy for big toe joint instability

PRP treatments involve collecting a small amount of your blood and spinning it in a centrifuge to separate the platelets from the red cells. The collected platelets are then injected into toe joints to stimulate healing and regeneration.

Stem cell therapy involves the use of bone marrow derived stem cells. These stem cells are also injected into to the joint to stimulate healing and regeneration.

The determination of which treatment is used is made during the initial consultation and physical examination of the toe. Afterwards we discuss with the patient the realistic healing options that these treatment can offer them.

The goal of the treatment is to stabilize the big toe and prevent the formation of a bunion.

  • PRP and stem cell therapy work similarly to repair loose damaged ligaments which allow the bones of the toe to move in abnormal ways and lead to a grinding that destroys the joint’s cartilage.
  • The treatments also work on the tendon attachments to the bones. This damage allows the muscles of the toe to hyperflex, injuring both the muscle and allowing the joint the abnormal motion that damages the cartilage.

A December 2018 study (2) evaluated clinical improvement in a population of elite dancers following treatment with ultrasound-guided platelet-rich plasma (PRP) injections of various lower extremity sites by assessing when they were able to return to dance.

  • Nineteen dancers (13 female, 6 male; ages 15 to 42) were treated between 2009 and 2016 at sites that included: hamstring tendon (1), proximal iliotibial band (1), patellar tendon (3), posterior tibial tendon (5), peroneus brevis tendon (3), plantar fascia (3), and the first metatarsophalangeal (MTP) joint capsule (3).
  • All patients adhered to standard post-care instructions, including non-weightbearing and avoidance of NSAIDs for at least 2 weeks post-injection.
  • Eighteen subjects achieved return to dance, 13 in 6 months or less, and the majority (10) within 3 months of injection. Five subjects required more than 6 months recovery time. These cases all involved foot and ankle sites; of these, two subjects required repeat injections, and both returned to dance within 11 months of the second injection

It should be pointed out that we carry out a more aggressive treatment protocol for dancers and athletes that need to return to activity as quickly as possible. One treatment is not one injection.

Stem Cell Therapy for cartilage repair

There is not much research on stem cell therapy for big toe arthritis pain. There is a lot of research on osteoarthritis. You can find this research in my article on stem cell therapy. Many doctors have noted empirically that stem cell therapy helps many people with toe pain. In our practice, Stem Cell Therapy is a treatment for musculoskeletal disorders. We treat degenerative joint disease, degenerative disc disease of the spine, and tendon and ligament injury. We offer stem cells drawn from patient’s own bone marrow. Stem cells are “de-differentiated pluripotent” cells, which means that they continue to divide to create more stem cells; these eventually “morph” into the tissue needing repair — for our purposes, collagen, bone, and cartilage.

Is Bunion shaving necessary?

Bunion shaving is not always the answer. Shaving down the bunion will provide some people with immediate relief and a more natural looking toe. However, research in showing us that shaving down the bunions is far from the end of the story. This is from a recent study in the journal Clinical biomechanics.(3) Here researchers wrote: “. . . our study showed that the hallux valgus deformity is not only a problem of the foot’s structure and function but also affects the entire lower limb and even the pelvis motion during walking. Surgical correction of the deformed segment (the bunion) itself could only correct skeletal alignment. However, (shaving the bunion down) does not solve functional related problems that occur during walking that are probably related with the cause of the problem . . . ” Simply, shaving the bunion down does not correct the problem of what caused the bunion to form in the first place. If the instability in the toe and foot are not corrected, the bunion will form again.

In the patient who has significant bunion formation, bunion removal may be needed. For others, correcting the problem of toe and foot instability may provide enough treatment to correct the alignment of the toe and eliminate the need for surgery. The recommendation for or against surgery is always best made after an examination.

Do you have questions? Ask Dr. Darrow

Marc Darrow, MD., JD. is the medical director and founder of the Darrow Stem Cell Institute in Los Angeles, California. With over 23 years experience in regenerative medicine techniques and the treatment of thousands of patients, Dr. Darrow is considered a leading pioneer in the non-surgical treatment of degenerative Musculoskeletal Disorders and sports related injuries. Dr. Darrow has co-authored and continues to co-author leading edge medical research including the use of bone marrow derived stem cell therapy for shoulder, hip, knee and spinal disorders.

A leading provider of stem cell therapy, platelet rich plasma and prolotherapy

PHONE: (800) 300-9300 or 310-231-7000

Stem cell and PRP injections for musculoskeletal conditions are not FDA approved. We do not treat disease. We do not offer IV treatments. There are no guarantees that this treatment will help you. Prior to our treatment, seek advice from your medical physician.

Neither Dr. Darrow, nor any associate, offer medical advice from this transmission. This information is offered for educational purposes only. The transmission of this information does not create a physician-patient relationship between you and Dr. Darrow or any associate. We do not guarantee the accuracy, completeness, usefulness or adequacy of any resource, information, product, or process available from this transmission. We cannot be responsible for the receipt of your email since spam filters and servers often block their receipt. If you have a medical issue, please call our office. If you have a medical emergency, please call 911.


1 Nery C, Fonseca LF, Gonçalves JP, Mansur N, Lemos A, Maringolo L. First MTP joint instability—Expanding the concept of “Turf-toe” injuries. Foot and Ankle Surgery. 2018 Nov 22.
2 Jain N, Bauman PA, Hamilton WG, Merkle A, Adler RS. Can Elite Dancers Return to Dance After Ultrasound-Guided Platelet-Rich Plasma (PRP) Injections?. J Dance Med Sci. 2018;22(4):225‐232. doi:10.12678/1089-313X.22.4.225
3 Klugarova J, Janura M, Svoboda Z, Sos Z, Stergiou N, Klugar M. Hallux valgus surgery affects kinematic parameters during gait. Clin Biomech (Bristol, Avon). 2016 Dec;40:20-26. doi: 10.1016/j.clinbiomech.2016.10.004. Epub 2016 Oct 6. PubMed PMID: 27792950; PubMed Central PMCID: PMC5325701.

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